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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Diversity of Archaea IV01:29

Diversity of Archaea IV

Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist thermal...
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
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Published on: June 7, 2020

Hyperthermia: malformations to chaperones.

Gregory D Bennett1

  • 1Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198-5805, USA. gbennett@unmc.edu

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

Exposure to hyperthermia, or elevated body temperature, during early embryonic development can cause birth defects. The precise molecular pathways linking heat stress to developmental abnormalities remain largely unknown, necessitating further research.

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Published on: December 18, 2013

Area of Science:

  • Developmental biology
  • Teratology
  • Molecular toxicology

Background:

  • Hyperthermia is a known teratogen, inducing malformations in animal models and associated with human abnormalities.
  • Early embryonic development, particularly neural development, is highly sensitive to heat stress.
  • While cell death from heat exposure is recognized, the molecular mechanisms translating heat stress into specific cellular dysfunction are unclear.

Purpose of the Study:

  • To review animal and clinical observations of hyperthermia-induced developmental abnormalities.
  • To outline scientific investigations into the effects of hyperthermia on embryonic development.
  • To better understand the morphological, biochemical, and molecular consequences of embryonic heat exposure.

Main Methods:

  • Review of existing animal model studies.
  • Analysis of clinical observations in humans.
  • Synthesis of research characterizing hyperthermia's effects on developing embryos.

Main Results:

  • Hyperthermia exposure during critical developmental windows leads to malformations.
  • Heat stress impacts embryonic development at morphological, biochemical, and molecular levels.
  • Specific molecular pathways linking heat exposure to developmental defects require further elucidation.

Conclusions:

  • Hyperthermia poses a significant risk to embryonic development, especially during early stages.
  • Understanding the molecular basis of heat-induced teratogenesis is crucial for prevention and intervention.
  • Further research is needed to fully characterize the multifaceted effects of hyperthermia on the developing embryo.