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Updated: Jun 9, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Intensive insulin therapy versus conventional insulin therapy for critically ill trauma patients admitted to ICU
Abdulaziz S Aldawood1, Hani M Tamim, Mohammed A Alsultan
1Department of Intensive Care Medicine, College of Medicine, King Abdulaziz Medical City and King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Purpose:
The objective of our study was to evaluate the beneficial effect of IIT in reducing mortality and morbidity in critically ill trauma patients admitted to ICU.
Method And Material:
Nested cohort study within a Randomized Controlled Trial. All trauma patients with GCS < or = 9 included in the original trial were included in this study. Primary outcome was ICU mortality.
Result:
There was no difference in ICU mortality between IIT and CIT groups (6.5% vs. 5.5%, p = 0.67). After adjustment for baseline characteristics, IIT therapy was also not associated with mortality (Adjusted Hazard Ratio 1.33, 95% CI 0.35-5.05). IIT therapy was associated with a significant increase in the incidence of hypoglycemia as compared to CIT, at least one hypoglycemia episode occurred in 18.5% of patients in IIT and 1.3% in the CIT group (P < 0.0001).
Conclusion:
IIT was not associated with survival improvement in trauma patients admitted to ICU and was associated with increased incidence of hypoglycemia.
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