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Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort

M Herr1, B Clarisse, L Nikasinovic

  • 1Laboratoire Santé Publique et Environnement, Faculté des Sciences Pharmaceutiques et Biologiques,Université Paris Descartes, 4 avenue de l’Observatoire, Paris, France.

Allergy
|September 1, 2010
PubMed

Insights

Allergic rhinitis (AR) symptoms can appear in toddlers as young as 18 months. Early diagnosis is supported by a family history of AR or biological markers like blood eosinophilia and sensitization to allergens.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Epidemiology

Background:

  • Early onset of allergic rhinitis (AR) is understudied, with symptoms often misattributed to infections.
  • The PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort provides a unique dataset to investigate infant atopy and AR-like symptoms.

Purpose of the Study:

  • To analyze the relationship between allergic rhinitis-like symptoms and atopy in infants.
  • To identify early indicators for allergic rhinitis in toddlers.

Main Methods:

  • AR-like symptoms (rhinorrhea, nasal congestion, sneezing) were assessed via questionnaire at 18 months in the PARIS cohort.
  • Parental allergy history and infant atopy markers (blood eosinophilia, total IgE, specific IgE) were evaluated.
  • Multivariate logistic regression adjusted for confounders was used to study associations.

Main Results:

  • 9.1% of 1850 toddlers reported AR-like symptoms in the past year.
  • Parental history of AR significantly increased the risk (OR 2.09).
  • Biological markers of atopy, particularly blood eosinophilia and house dust mite sensitization, were strongly associated with AR-like symptoms.

Conclusions:

  • Allergic rhinitis can manifest as early as 18 months of age.
  • Infants with a parental history of AR or biological evidence of atopy, especially blood eosinophilia and inhalant allergen sensitization, warrant increased suspicion for AR.
Abstract

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