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Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Other Stress Responses in Bacteria01:30

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Related Experiment Video

Updated: Jun 9, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

STAT3 modulates the DNA damage response pathway.

Seán P Barry1, Paul A Townsend, Richard A Knight

  • 1Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK.

International Journal of Experimental Pathology
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

The transcription factor STAT3 (Signal Transducer and Activator of Transcription 3) is crucial for efficient DNA repair. Cells lacking STAT3 show impaired DNA damage response and repair, highlighting its role in maintaining genomic stability.

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Last Updated: Jun 9, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

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Published on: September 28, 2012

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Signal Transducer and Activator of Transcription 3 (STAT3) is recognized for its anti-apoptotic and cytoprotective roles, particularly in cancer.
  • Oxidative stress, a condition involving DNA damage, has been linked to STAT3's protective functions.
  • The specific role of STAT3 in DNA damage response and repair pathways remained largely undescribed.

Purpose of the Study:

  • To investigate the role of STAT3 in the cellular response to DNA damage.
  • To determine if STAT3 influences the efficiency of DNA repair mechanisms.
  • To elucidate the molecular pathways through which STAT3 might mediate DNA damage response.

Main Methods:

  • Utilized cell models lacking STAT3 to assess DNA repair efficiency.
  • Measured the activity of key DNA damage sensing pathways, including ATM-Chk2 and ATR-Chk1.
  • Investigated the transcriptional regulation of DNA damage response mediators, such as MDC1, by STAT3.

Main Results:

  • Cells deficient in STAT3 exhibited significantly reduced efficiency in repairing damaged DNA.
  • STAT3-deficient cells displayed diminished activity in both the ATM-Chk2 and ATR-Chk1 DNA damage response pathways.
  • STAT3 was found to transcriptionally modulate MDC1, a critical regulator of the ATM-Chk2 pathway.

Conclusions:

  • STAT3 is essential for effective DNA damage repair.
  • STAT3 contributes to DNA repair by regulating the ATM-Chk2 and ATR-Chk1 signaling pathways.
  • These findings reveal a novel function for STAT3 in maintaining genomic integrity.