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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Jun 9, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Adiponectin and bone mass density: The InCHIANTI study.

Nicola Napoli1, Claudio Pedone, Paolo Pozzilli

  • 1Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Italy.

Bone
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

Adiponectin serum levels are inversely linked to bone mineral density (BMD) in women, but not men. This finding highlights potential sex differences in adiponectin

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Area of Science:

  • Endocrinology
  • Bone Biology
  • Gerontology

Background:

  • Previous studies suggest an inverse correlation between adiponectin and bone mineral density (BMD) in humans.
  • Existing data are limited by small sample sizes and inadequate control for body composition.

Purpose of the Study:

  • To investigate the association between serum adiponectin and BMD in a well-characterized cohort.
  • To examine potential sex-specific differences in this relationship, controlling for key confounders.

Main Methods:

  • Utilized data from the InCHIANTI study, including quantitative CT for BMD and bioimpedenziometry for body composition.
  • Measured serum adiponectin via radioimmunoassay, excluding participants with specific medical conditions or therapies.
  • Employed Pearson's correlation and linear regression to assess adiponectin's association with total, trabecular, and cortical BMD, adjusting for confounders.

Main Results:

  • The study included 320 men and 271 postmenopausal women.
  • Serum adiponectin was not independently associated with BMD in men.
  • In women, adiponectin showed a significant inverse association with total, trabecular, and cortical BMD after controlling for confounders.

Conclusions:

  • Adiponectin is inversely associated with bone mass in postmenopausal women.
  • Further prospective studies are required to validate these findings and elucidate underlying mechanisms.