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Validation of the pediatric cardiac quality of life inventory

Bradley S Marino1, Ryan S Tomlinson, Gil Wernovsky

  • 1Cincinnati Children's Hospital Medical Center, Department of Pediatrics, 3333 Burnet Ave, MLC 5050, Cincinnati, OH 45229, USA. bradley.marino@cchmc.org

Pediatrics
|September 1, 2010
PubMed

Insights

The Pediatric Cardiac Quality of Life Inventory (PCQLI) is a valid and reliable tool for assessing health-related quality of life in pediatric patients with heart disease. This finding supports its use in clinical research and patient management.

Area of Science:

  • Pediatric Cardiology
  • Health Outcomes Research
  • Quality of Life Measurement

Background:

  • Assessing health-related quality of life (HRQoL) in pediatric patients with heart disease (HD) is crucial for comprehensive care.
  • Existing tools may not fully capture the unique experiences of children and adolescents with cardiac conditions.

Purpose of the Study:

  • To confirm the validity and reliability of the Pediatric Cardiac Quality of Life Inventory (PCQLI) in a multicenter setting.
  • To establish the PCQLI as a dependable measure for pediatric populations with diverse heart conditions.

Main Methods:

  • A multicenter study involving 1605 pediatric patients (8-18 years) with HD and their parents.
  • Patients and parents completed the PCQLI alongside other validated instruments (PedsQL, SPPC/SPPA, YSR/CBCL).
  • Construct validity was assessed via correlations with disease severity, healthcare utilization, and other HRQoL/behavioral measures; test-retest reliability was also evaluated.

Main Results:

  • The PCQLI demonstrated strong construct validity, with lower scores correlating with disease severity (e.g., Fontan palliation, increased operations/admissions) (P<.001).
  • Moderate to excellent correlations were found between patient and parent PCQLI scores (r=0.41-0.61) and with other validated measures (r=0.28-0.76).
  • Excellent test-retest reliability was confirmed (r=0.78-0.90; P<.001).

Conclusions:

  • The PCQLI is a valid and reliable instrument for assessing quality of life in children and adolescents with congenital and acquired heart disease.
  • The PCQLI is suitable for use in future research and clinical practice to monitor patient well-being.
  • Findings support the PCQLI's utility in understanding the impact of heart disease on pediatric patients' lives.
Abstract

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