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Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
Thamara A Cafaro1, Stefanía Santo, Lucena A Robles
1CIBICI, Faculty of Chemistry, National University of Córdoba, Argentina.
Purpose:
To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls.
Methods:
Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues.
Results:
We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG).
Conclusions:
This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
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