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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Related Experiment Video

Updated: Jun 9, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

[Genodermatoses for practitioners--principles and concepts].

Peter H Itin1, Bettina Burger

  • 1Dermatologische Universitätsklinik Basel.

Therapeutische Umschau. Revue Therapeutique
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

Genetic and environmental factors influence disease phenotypes, especially in skin conditions. Understanding gene-environment interactions and epigenetics is crucial for diagnosing and treating genodermatoses.

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Last Updated: Jun 9, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Genetics
  • Dermatology
  • Epigenetics

Background:

  • Diseases arise from gene-environment interactions, with monogenic disorders caused by single mutations and polygenic disorders influenced by multiple genes.
  • The skin is frequently affected by genetic diseases, with over 350 identified genodermatoses.
  • Environmental factors significantly modify disease expression, as seen in Ichthyosis vulgaris and atopic dermatitis.

Purpose of the Study:

  • To explore the interplay between genetic mutations, environmental factors, and disease phenotypes.
  • To highlight the role of the Human Genome Project and ENCODE in advancing genetic understanding.
  • To emphasize the significance of epigenetics and microRNAs in skin gene regulation and disease.

Main Methods:

  • Review of genetic and environmental influences on disease phenotypes.
  • Discussion of diagnostic approaches for genodermatoses.
  • Exploration of the role of epigenetics and microRNAs in skin biology.

Main Results:

  • Genetic mutations, like filaggrin, contribute to skin conditions, with environmental factors modulating their severity.
  • The Human Genome Project and ENCODE aim to identify all genes and functional elements for diagnostics and therapy.
  • Epigenetics and microRNAs are critical regulators of gene function in the skin.

Conclusions:

  • Identifying key clinical features is vital for diagnosing genodermatoses and understanding their underlying genetic pathways.
  • Further research into gene-environment interactions and epigenetic mechanisms is essential for advancing dermatological treatments.