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Updated: Jun 9, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Postpartum hypothalamic dysfunction--a case report.

Robert Krysiak¹, Magdalena Olszanecka-Glinianowicz, Bogdan Marek

¹Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl

Endokrynologia Polska

|September 1, 2010

Summary

Hypothalamic dysfunction following childbirth is rare. This case study details a patient whose obesity, resistant to standard treatments, improved with bariatric surgery, offering insights into hormonal regulation.

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Area of Science:

Endocrinology
Neuroscience

Background:

Hypothalamic dysfunction is a rare endocrine disorder affecting brain function and hormone regulation.
It presents with diverse symptoms including headaches, behavioral changes, sleep and temperature dysregulation, and hormonal imbalances.

Observation:

A 29-year-old female developed hypothalamic dysfunction after delivery complications.
Diagnosis involved extensive laboratory and imaging studies.
Obesity associated with the condition was refractory to diet and medication.

Findings:

Bariatric surgery was effective in reducing body mass in the patient.
This case is the first to assess plasma levels of adipokines, neuropeptides, and gut hormones in postpartum hypothalamic dysfunction.
These hormones are crucial for regulating food intake.

Implications:

This study highlights bariatric surgery as a potential treatment for obesity in hypothalamic dysfunction.
Assessing specific hormones offers new insights into the pathophysiology of this rare condition.
Further research may elucidate the role of these hormones in postpartum hypothalamic dysfunction and obesity.