Clinical characteristics of Polish women with ST-segment elevation myocardial infarction
Marcin Sadowski1, Mariusz Gasior, Marek Gierlotka
1Swietokrzyskie Cardiology Centre, Kielce, Poland. emsad@o2.pl
Insights
Women with ST-segment elevation myocardial infarction (STEMI) present with poorer clinical characteristics and face longer treatment delays compared to men. This leads to significantly higher in-hospital and 12-month mortality rates for women experiencing STEMI.
Area of Science:
- Cardiology
- Public Health
- Gender Medicine
Background:
- Acute coronary syndromes exhibit distinct clinical patterns, treatment approaches, and prognoses between men and women.
- Understanding these sex-based differences is critical for effective cardiovascular disease management.
Purpose of the Study:
- To delineate the clinical profile of Polish women diagnosed with ST-segment elevation myocardial infarction (STEMI).
Main Methods:
- Analysis of 26,035 STEMI patients (34.5% female) from the Polish Registry of Acute Coronary Syndromes (PL-ACS) between June 2005 and May 2006.
- Comparison of clinical characteristics, treatment delays, and mortality between female and male STEMI patients.
Main Results:
- Women with STEMI were older and presented with a higher incidence of risk factors, anterior infarctions, and cardiac complications like pulmonary edema and cardiogenic shock.
- Coronary angiography was less frequently performed in women, and they experienced longer delays in treatment initiation.
- In-hospital and 12-month mortality rates were significantly elevated in women compared to men.
Conclusions:
- Women with STEMI demonstrate poorer baseline clinical characteristics and face significant delays across all treatment stages.
- Less frequent application of invasive strategies in women correlates with poorer outcomes.
- Despite similar independent predictors of death, overall mortality remains higher in women post-STEMI.
Background:
Differences in clinical manifestation, therapeutic strategies and prognosis in men and women with acute coronary syndromes became crucial in the last decade.
Aim:
To present clinical characteristics of Polish women with ST-segment elevation myocardial infarction (STEMI).
Methods:
A total of 26,035 patients with STEMI (8989 females, 34.5%) were included between 01.06.2005 and 31.05.2006. Data were obtained from the Polish Registry of Acute Coronary Syndromes (PL-ACS).
Results:
Women were older than men. The incidence of classical risk factors, anterior infarction, atrial fibrillation, higher heart rate, cardiac arrest, pulmonary oedema and cardiogenic shock was higher in women. Coronary angiography was performed in 58.7% of patients, significantly less in women. There was a longer time delay in women at each stage of treatment. In-hospital and 12-month mortality was significantly higher in women. Pulmonary oedema, cardiogenic shock, cardiac arrest, age, diabetes and anterior infarction were independent factors of risk of death in multifactorial analyses, both in in-hospital and long term observation.
Conclusions:
Basic clinical characteristics of women with STEMI is poorer than in men. Women have longer time delay at each stage of treatment. Invasive strategy was less frequently applied in women. Independent predictors of death are similar in men and in women. Both in-hospital and one year mortality is higher in women.
Related Concept Videos
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Angina III: Clinical Manifestations and Assessment
Coronary Artery Disease III: Clinical Manifestations

