Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The HLA system and habitual abortion].

A Hajek-Rosenmayr1

  • 1Institut für Blutgruppenserologie, Universität Wien.

Wiener Medizinische Wochenschrift (1946)
|January 1, 1990
PubMed
Summary

Human Leukocyte Antigen (HLA) compatibility is crucial for successful organ transplants and bone marrow transplantation. Mismatched HLA antigens can lead to transplant rejection and reduced function, while matching improves outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of HLA phenotypes on the inhibition of in vitro alloreactivity by cyclosporine.

Transplantation·1990
Same author

Activated human T lymphocytes express MHC class I heavy chains not associated with beta 2-microglobulin.

The Journal of experimental medicine·1990
Same author

HLA-C locus antigens seen by one-dimensional isoelectric focusing: definition of the so far known HLA-C specificities and of two subtypes.

Human immunology·1989
Same author

[Serologic diagnosis and therapeutic possibilities in habitual abortion].

Wiener klinische Wochenschrift·1989
Same author

Lack of association between HLA antigens and bulimia.

Biological psychiatry·1989
Same author

Biochemical HLA typing: a population study in 112 Caucasians.

Tissue antigens·1989

Area of Science:

  • Immunogenetics
  • Transplantation immunology

Context:

  • Human Leukocyte Antigen (HLA) system exhibits extreme polymorphism, with over 398 million possible HLA phenotypes considering HLA-A, -B, -C, and -DR antigens.
  • HLA antigens are key determinants of immune recognition, influencing transplant rejection and graft-versus-host disease.

Purpose:

  • To highlight the critical role of HLA antigen compatibility in organ and bone marrow transplantation.
  • To underscore the significance of HLA matching for successful transplant outcomes and to note its implications in pregnancy.

Summary:

  • HLA antigen incompatibility between recipients and donors is linked to shorter transplant function periods.
  • Conversely, HLA compatibility is associated with improved and prolonged transplant function.
  • HLA matching is essential for solid organ transplantation, particularly kidneys, and absolutely necessary for bone marrow transplantation.

Impact:

  • Ensuring HLA compatibility significantly enhances the success rates and longevity of transplanted organs and bone marrow.
  • Understanding HLA compatibility is vital for minimizing post-transplant complications like rejection and graft-versus-host disease.
  • High HLA compatibility between mother and child may increase the risk of habitual abortion, indicating a complex role beyond transplantation.

Related Experiment Videos