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Hematologic and hemostatic changes induced by different columns during LDL apheresis
Anders Hovland1, Randolf Hardersen, Erik Waage Nielsen
1Coronary Care Unit, Department of Internal Medicine, Nordland Hospital, Bodø, Norway. anders.w.hovland@gmail.com
Journal of Clinical Apheresis
|September 1, 2010
Summary
Different low density lipoprotein (LDL) apheresis columns significantly impact hematological and hemostatic risk factors. These findings are crucial for long-term familial hypercholesterolemia management.
Area of Science:
- Cardiology
- Hematology
- Biochemistry
Background:
- Low density lipoprotein (LDL) apheresis is a vital long-term therapy for familial hypercholesterolemia.
- Assessing the impact of LDL apheresis on non-lipoprotein risk factors is essential for comprehensive patient management.
Purpose of the Study:
- To compare the effects of three distinct LDL apheresis columns (DL-75, LA-15, EC-50W) on hematological and hemostatic parameters.
- To evaluate the differential impact of these apheresis columns on risk factors beyond lipoproteins.
Main Methods:
- Three patients with familial hypercholesterolemia underwent six LDL apheresis treatments using DL-75, LA-15, and EC-50W columns in random order.
- Key parameters measured included hemoglobin, leukocytes, platelets, fibrinogen, thrombin-antithrombin complexes (TAT), plasminogen activator inhibitor-1 (PAI-1), and homocysteine.
Main Results:
- DL-75 significantly decreased hemoglobin, leukocytes, and platelets, while LA-15 and EC-50W increased hemoglobin and leukocytes.
- All columns significantly reduced fibrinogen and PAI-1, with varying degrees of reduction and significant inter-column differences observed.
- TAT levels increased significantly across all columns, with notable differences between DL-75 and EC-50W.
Conclusions:
- The three LDL apheresis columns demonstrate distinct effects on critical hematological and hemostatic risk factors.
- These differential impacts highlight the importance of column selection in managing overall cardiovascular risk in patients undergoing LDL apheresis.
