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[Molecular predictors in head and neck tumours]

P Smilek1

  • 1Klinika otorinolaryngologie a chirurgie hlavy a krku, FN u sv. Anny v Brne a LF MU, Brno. smilek@med.muni.cz

Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
|September 3, 2010
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...