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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Testosterone and metabolic syndrome: a meta-analysis study.
Giovanni Corona1, Matteo Monami, Giulia Rastrelli
1Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
The Journal of Sexual Medicine
|September 3, 2010
Summary
Metabolic syndrome (MetS) is independently associated with low testosterone in men. Testosterone replacement therapy (TRT) shows promise in improving metabolic control and reducing central obesity in men with MetS.
Area of Science:
- Endocrinology
- Metabolic Health
- Male Reproductive Health
Background:
- Metabolic syndrome (MetS) is frequently linked to male hypogonadism.
- The precise role of testosterone replacement therapy (TRT) in managing MetS remains unclear.
Purpose of the Study:
- To systematically review and meta-analyze the relationship between androgen levels and MetS.
- To assess the metabolic effects of TRT through a meta-analysis of randomized clinical trials (RCTs).
Main Methods:
- Conducted an extensive Medline search using keywords: "testosterone," "metabolic syndrome," and "males."
- Included 20 studies: 13 cross-sectional, 3 longitudinal, and 4 RCTs, plus one unpublished RCT.
- Performed meta-analyses and meta-regression to analyze data.
Main Results:
- MetS patients exhibited significantly lower testosterone levels compared to healthy individuals.
- Type 2 diabetes (T2DM) exacerbated the testosterone decline associated with MetS.
- TRT significantly reduced fasting glucose, HOMA-IR, triglycerides, and waist circumference, while increasing HDL cholesterol.
Conclusions:
- MetS is an independent predictor of male hypogonadism.
- TRT appears to improve metabolic parameters and reduce central obesity in men with MetS.
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