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Effects of a novel PAF antagonist, E6123, on passive anaphylaxis
Y Sakuma1, H Tsunoda, S Katayama
1Tsukuba Research Lab., Eisai Co., Ltd., Ibaraki, Japan.
Agents and Actions. Supplements
|January 1, 1990
Abstract:
E6123 inhibited antigen-induced bronchoconstriction, the development of bronchial hyperreactivity and eosinophil infiltration in the airway in passively sensitized guinea pigs and protected mice from anaphylactic death. The inhibitory effects of E6123 on anaphylactic response were very potent compared with those of WEB 2347 and Y-24180.