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Plasticisers, another burden for asthmatics?

C J Doelman¹, P J Borm, A Bast

¹Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

Agents and Actions. Supplements

|January 1, 1990

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Di(2-ethylhexyl)phthalate (DEHP) exposure may lead to bronchial hyperresponsiveness. Its metabolite, mono(2-ethylhexyl)phthalate (MEHP), was shown to increase airway reactivity in rat tracheal tissue.

Area of Science:

Toxicology
Pulmonary Medicine
Pharmacology

Background:

Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer with known toxicological effects on lung tissue.
Previous studies indicate DEHP inhalation can cause pulmonary edema and asthma, while intravenous injection leads to lung inflammation and hemorrhage.

Purpose of the Study:

To investigate the potential of DEHP to induce bronchial hyperresponsiveness.
To examine the effect of DEHP's metabolite, mono(2-ethylhexyl)phthalate (MEHP), on airway reactivity.

Main Methods:

In vitro assessment of MEHP's effect on methacholine dose-response curves in rat tracheal tissue.
Evaluation of dose-dependent changes in EC50 and maximal effect.

Main Results:

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MEHP induced a dose-dependent increase in the negative logarithm of the EC50 for methacholine.
MEHP also caused a decrease in the maximal effect of the methacholine dose-response curve.
These findings suggest MEHP alters airway smooth muscle responsiveness.

Conclusions:

DEHP, through its metabolite MEHP, may cause bronchial hyperresponsiveness.
The study highlights a potential mechanism for DEHP-induced respiratory issues.
Further in vivo studies are warranted to confirm these findings in a whole organism context.