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Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
[Blood oxygenation level dependent (BOLD)--renal imaging: concepts and applications]
Johanna C Nissen1, Moritz B Mie, Frank G Zöllner
1Institut für Klinische Radiologie und Nuklearmedizin, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Ruprecht-Karls-Universität Heidelberg, D-68167 Mannheim. Johanna.nissen@umm.de
Zeitschrift Fur Medizinische Physik
|September 3, 2010
Summary
Blood oxygenation level dependent (BOLD) imaging offers a non-invasive way to assess kidney oxygenation and blood flow, aiding in the study of renal diseases and drug effects.
Area of Science:
- Biomedical Imaging
- Renal Physiology
- Magnetic Resonance Imaging
Context:
- Renal diseases and pharmacons alter kidney blood flow and oxygenation.
- Assessing these changes non-invasively is crucial for diagnosis and treatment monitoring.
Purpose:
- To provide an overview of current Blood Oxygenation Level Dependent (BOLD) imaging studies in renal applications.
- To explore the potential of BOLD imaging in clinical settings for evaluating renal function.
Summary:
- Blood Oxygenation Level Dependent (BOLD) imaging utilizes T2*-weighted sequences to detect changes in local field inhomogeneities.
- This non-invasive MRI technique estimates renal and medullary oxygenation and indirectly measures blood flow without contrast agents.
- BOLD imaging allows for the observation and control of drug effects on the kidney and the progression of renal diseases.
Impact:
- Facilitates non-invasive monitoring of renal oxygenation and blood flow.
- Enables better understanding and management of renal diseases.
- Supports the clinical application of BOLD imaging for kidney research and patient care.
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