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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

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Published on: March 29, 2019

Selenium and bladder cancer risk: a meta-analysis.

André F S Amaral¹, Kenneth P Cantor, Debra T Silverman

¹Spanish National Cancer Research Centre, Genetic and Molecular Epidemiology Group, Madrid, Spain.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

|September 3, 2010

Summary

High selenium intake may reduce bladder cancer risk, particularly in women. Further research is needed to confirm this protective effect of selenium against bladder cancer.

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Area of Science:

Nutritional biochemistry
Cancer epidemiology
Environmental health

Background:

Selenium is an antioxidant with potential inverse associations with various cancer risks.
Previous studies suggest a link between selenium levels and bladder cancer risk.
This meta-analysis specifically investigates serum and toenail selenium levels in relation to bladder cancer.

Purpose of the Study:

To meta-analyze the association between selenium levels (serum and toenail) and bladder cancer risk.
To explore potential sources of heterogeneity in the observed associations.

Main Methods:

Meta-analysis of seven epidemiologic studies (case-control, nested case-control, case-cohort) published before March 2010.
Calculation of meta-odds ratios (mOR) and 95% confidence intervals (CI) using fixed and random effects models.

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Assessment of heterogeneity using the I(2) statistic.

Main Results:

Overall inverse association found between elevated selenium levels and bladder cancer risk (mOR = 0.61; 95% CI, 0.42-0.87).
Inverse association was stronger in women (mOR = 0.55; 95% CI, 0.32-0.95) compared to men (mOR = 0.95; 95% CI, 0.69-1.27).
Potential sources of heterogeneity included sex, sample type, smoking status, and study design.

Conclusions:

Selenium may have a protective effect against bladder cancer, notably in women, possibly due to gender-specific differences in selenium metabolism.
Heterogeneity was largely attributed to variations in biological sample types used for selenium measurement and small study sizes.
Results suggest a beneficial role of high selenium intake for bladder cancer risk, warranting further investigation in larger studies.