Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute renal failure in man: new aspects concerning pathogenesis. A morphometric study.

A Bohle1, J Christensen, F Kokot

  • 1Institute of Pathology, University of Tübingen, FRG.

American Journal of Nephrology
|January 1, 1990
PubMed
Summary

Acute renal failure (ARF) involves tubular epithelial cell swelling and interstitial widening. Juxtaglomerular apparatuses (JGAs) play a critical role in ARF pathogenesis, especially in myeloma kidney cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Type 1 Diabetes Mellitus in the First Years of Life - Onset, Initial Treatment, and Early Disease Course.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2024
Same author

scCODA is a Bayesian model for compositional single-cell data analysis.

Nature communications·2021
Same author

[Intravesical gene therapy for patients with BCG-refractory NMIBC?]

Der Urologe. Ausg. A·2021
Same author

Biomass production and nitrogen content of C<sub>3</sub>- and C<sub>4</sub>- grasses in pure and mixed culture with different nitrogen supply.

Oecologia·2017
Same author

[Non-cardiac and non-pulmonary causes of dyspnea].

Der Internist·2015
Same author

Evaluation of peptide selection approaches for epitope-based vaccine design.

Tissue antigens·2014

Area of Science:

  • Nephrology
  • Pathology
  • Renal Physiology

Background:

  • Acute renal failure (ARF) is a complex condition affecting kidney function.
  • Understanding the structural changes in ARF is crucial for identifying pathogenic mechanisms.

Purpose of the Study:

  • To conduct a morphometric investigation of kidney structures in various phases of human ARF.
  • To elucidate the role of juxtaglomerular apparatuses (JGAs) and tubular changes in ARF pathogenesis.

Main Methods:

  • Morphometric analysis of proximal tubules, distal tubules, cortical interstitium, capillaries, renal corpuscles, and JGAs.
  • Comparison of 56 ARF cases (oligoanuric, polyuric, normuric phases), 6 myeloma kidney cases, and 21 control kidneys.

Main Results:

Related Experiment Videos

  • Main pathological change in ARF is epithelial cell swelling in proximal and distal tubules; necrosis is usually single-cell.
  • Significant interstitial widening observed in the cortex and outer medulla in most ARF cases.
  • JGAs were significantly larger in the oligoanuric phase of ARF and smaller in myeloma kidneys with occluding casts.

Conclusions:

  • Glomerular filtration rate (GFR) fall in post-shock ARF is not due to urine back-diffusion or interstitial edema.
  • Occluding casts in myeloma kidney lead to tubular atrophy and narrowed lumens, not widened tubules.
  • JGAs, renin-angiotensin II, and adenosine are critical in ARF pathogenesis; adenosine contributes to irreversible GFR drop in myeloma kidney ARF.