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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Divergent roles of 25-hydroxyvitamin D<sub>3</sub> and 1α,25-dihydroxyvitamin D<sub>3</sub> in neural fate determination: A CYP27B1-dependent neuron formation and VDR-dependent astrocyte development.

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Development of a predictive scoring system for vitamin D deficiency 'Vitamin D Deficiency Predicting Scoring (ViDDPreS)' based on the vitamin D status in young Japanese women: a nationwide cross-sectional study.

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Blood 25-hydroxyvitamin D<sub>3</sub> concentration of Japanese Black cattle at two farms with different rearing environments, Kagoshima prefecture, Japan.

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The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism.

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Vitamin D<sub>3</sub> Promotes Not Motor Coordination but Motor Skill Learning without Influence on Muscle Function.

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Related Experiment Video

Updated: Jun 9, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

[Vitamin K and fracture].

Naoko Tsugawa1, Toshio Okano

  • 1Department of Hygienic Sciences, Kobe Pharmaceutical University.

Clinical Calcium
|September 3, 2010
PubMed
Summary

Vitamin K is crucial for blood clotting and bone health. Research indicates potential bone vitamin K insufficiency, even with adequate levels for coagulation, highlighting fracture risk.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Orthopedics

Context:

  • Vitamin K is essential for synthesizing blood coagulation factors.
  • Vitamin K plays a key role in bone metabolism through gamma-carboxylation of specific proteins.
  • Emerging evidence suggests potential vitamin K insufficiency in bone tissue.

Purpose:

  • To review studies investigating the relationship between vitamin K status and fracture risk.
  • To explore the dual role of vitamin K in hemostasis and skeletal health.
  • To highlight the discrepancy between vitamin K sufficiency for coagulation and potential bone deficiency.

Summary:

  • Vitamin K is vital for synthesizing blood clotting factors.
  • It also supports bone health by enabling carboxylation of proteins like osteocalcin.

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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation
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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation

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Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
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Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

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Last Updated: Jun 9, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation
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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation

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Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
06:59

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

  • Studies suggest bone may have insufficient vitamin K even when blood levels are adequate, impacting fracture risk.

    • Impact:

    • This review consolidates current research on vitamin K and fractures.
    • It underscores the importance of assessing vitamin K status for skeletal health.
    • Findings may inform future nutritional guidelines and fracture prevention strategies.