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Physical activity and Alzheimer disease course
Nikolaos Scarmeas1, Jose A Luchsinger, Adam M Brickman
1Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, NY 10032, USA. ns257@columbia.edu
Summary
Engaging in physical activity (PA) is linked to a reduced risk of Alzheimer disease (AD). Higher levels of PA are associated with prolonged survival in individuals diagnosed with AD, suggesting exercise impacts disease course.
Area of Science:
- Neurology
- Gerontology
- Public Health
Background:
- Physical activity (PA) is associated with a reduced risk of Alzheimer disease (AD).
- The impact of PA on the course of established AD has not been previously investigated.
- Understanding factors influencing AD progression is crucial for patient care and public health strategies.
Purpose of the Study:
- To investigate the association between physical activity levels and the course of Alzheimer disease.
- To determine if physical activity influences mortality and cognitive decline in individuals with incident AD.
Main Methods:
- A population-based prospective study of 357 individuals aged 65+ in New York.
- Participants were nondemented at baseline and diagnosed with AD during follow-up.
- Physical activity was assessed and analyzed using Cox and generalized estimating equation models, adjusting for multiple covariates.
Main Results:
- Individuals with incident AD who engaged in some or much physical activity had a lower risk of mortality compared to inactive individuals.
- Higher levels of physical activity were associated with even lower mortality risk.
- Physical activity did not significantly affect the rates of cognitive or functional decline in AD patients.
Conclusions:
- Physical activity may influence not only the risk but also the duration and survival of Alzheimer disease.
- Increased physical activity is associated with prolonged survival in individuals with Alzheimer disease.
- These findings highlight the potential role of exercise in managing Alzheimer disease progression.
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