Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the Milestones: Data and Decision-Making in Otolaryngology Clinical Competency Committees.

The Laryngoscope·2025
Same author

Improving the Observed-to-Expected Mortality Ratio with the Combination of Standardized Documentation and a Multidisciplinary Mortality Review Committee.

Applied clinical informatics·2025
Same author

A Minimally Invasive Approach to Caecal Volvulus: A Rare Complication of Colonoscopy.

Cureus·2025
Same author

Changes in Otolaryngology Residency Websites Since Preference Signaling Began.

The Laryngoscope·2025
Same author

Robotic left-sided intracorporeal anastomosis with indocyanine green - A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2025
Same author

A Scoping Review of the Diagnosis and Operative Management of Water Bead Ingestion by Children.

Journal of pediatric surgery·2025
Same journal

Advances in patient-specific 3D-printed models in temporal bone surgery.

Current opinion in otolaryngology & head and neck surgery·2026
Same journal

Graduated autonomy in head and neck microvascular surgery fellowship training: oncologic and reconstructive competency, safety, and educational implications.

Current opinion in otolaryngology & head and neck surgery·2026
Same journal

Costs and system-wide considerations within head and neck reconstruction: moving toward a value-based care framework.

Current opinion in otolaryngology & head and neck surgery·2026
Same journal

Modern methods of dorsal augmentation rhinoplasty.

Current opinion in otolaryngology & head and neck surgery·2026
Same journal

Flap selection for circumferential pharyngeal reconstruction.

Current opinion in otolaryngology & head and neck surgery·2026
Same journal

Improving facial scar outcomes: an evidence-based update.

Current opinion in otolaryngology & head and neck surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

Round window perfusion dynamics: implications for intracochlear therapy.

Sarah N Bowe1, Abraham Jacob

  • 1Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus, Ohio 43212, USA.

Current Opinion in Otolaryngology & Head and Neck Surgery
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

Novel drug delivery methods for inner ear diseases show promise, offering improved pharmacokinetics over traditional systemic administration. These advancements may lead to new treatments for hearing loss, tinnitus, and vestibular disorders.

More Related Videos

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy
09:52

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy

Published on: September 21, 2021

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

Related Experiment Videos

Last Updated: Jun 9, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy
09:52

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy

Published on: September 21, 2021

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

Area of Science:

  • Otolaryngology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Traditional systemic drug administration for inner ear diseases has limitations.
  • Intratympanic and intracochlear drug delivery represent a paradigm shift in treatment.
  • Advances in drug delivery are crucial for managing complex inner ear conditions.

Purpose of the Study:

  • To review the background and recent developments in intratympanic and intracochlear drug delivery for inner ear diseases.
  • To explore novel technologies and their potential impact on otologic treatment.

Main Methods:

  • Review of current literature on inner ear drug delivery systems.
  • Analysis of emerging technologies in preclinical and clinical development.

Main Results:

  • Several novel drug delivery techniques show significant promise, including the Silverstein MicroWick, round window microcatheter, hydrogels, biopolymers, nanoparticles, specialized cochlear implant arrays, osmotic pumps, and perfusion systems.
  • Animal studies indicate sustained delivery systems offer more reliable inner ear pharmacokinetics compared to systemic and intratympanic methods.
  • These technologies are in various stages of clinical development.

Conclusions:

  • Technological advancements in drug delivery must align with progress in treating inner ear diseases.
  • Promising treatment options for sensorineural hearing loss, tinnitus, and vestibular disorders are anticipated.
  • These innovations may herald a new era in otology.