Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.

Science translational medicine·2026
Same author

Living Life to the Fullest After Organ Transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Donor-reactive clonotypes are overrepresented in the urinary T cell repertoire during kidney transplant rejection and show distinct dynamics in the circulation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

The Top 12 Most Impactful Papers in Clinical Transplantation in 2025: TI Editors' Choice.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Transplant International: Looking Back at 2025, Looking Forward to 2026.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Preclinical and clinical developments in Treg therapy for heart transplantation: Critical assessment and translational challenges.

Human immunology·2026
Same journal

Beyond consent: community engagement, benefit sharing and reciprocity in kidney genomics research.

Nature reviews. Nephrology·2026
Same journal

The social needs of patients with kidney failure.

Nature reviews. Nephrology·2026
Same journal

Long-term kidney protection in IgA nephropathy with atrasentan.

Nature reviews. Nephrology·2026
Same journal

Benefits of finerenone treatment across chronic kidney disease aetiologies.

Nature reviews. Nephrology·2026
Same journal

The versatile roles of long non-coding RNAs in kidney disease.

Nature reviews. Nephrology·2026
Same journal

Sequential therapeutic approach for the management of osteoporosis in people with chronic kidney disease.

Nature reviews. Nephrology·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Transplantation tolerance through mixed chimerism.

Nina Pilat1, Thomas Wekerle

  • 1Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, 1090 Vienna, Austria.

Nature Reviews. Nephrology
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

Establishing immune tolerance through mixed chimerism can improve organ transplant survival. This approach, using donor bone marrow, aims to reduce reliance on immunosuppressive drugs and their side effects.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
12:24

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

Related Experiment Videos

Last Updated: Jun 9, 2026

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
12:24

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Regenerative Medicine

Background:

  • Host immune response and immunosuppressive drugs limit organ transplant success.
  • Inducing donor-specific tolerance is key to improving transplant outcomes.
  • Mixed chimerism offers a promising strategy for achieving immune tolerance.

Purpose of the Study:

  • To review recent advances in inducing transplantation tolerance via mixed chimerism.
  • To discuss the potential and challenges of mixed chimerism in clinical practice.
  • To highlight strategies for overcoming limitations of current bone marrow transplantation protocols.

Main Methods:

  • Review of preclinical and clinical studies on mixed chimerism for transplantation tolerance.
  • Analysis of conditioning protocols for achieving mixed chimerism.
  • Evaluation of outcomes in organ transplantation models using mixed chimerism.

Main Results:

  • Mixed chimerism effectively induces donor-specific tolerance in transplantation models.
  • Conventional bone marrow transplantation protocols for mixed chimerism have significant toxicities.
  • Recent advances show promise in mitigating side effects and improving efficacy.

Conclusions:

  • Mixed chimerism holds significant potential for improving organ transplant survival and reducing immunosuppression.
  • Overcoming the toxicities associated with current protocols is crucial for clinical application.
  • Further research into refined conditioning and transplantation methods is warranted.