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Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice
Published on: February 18, 2022
Investigation of molecular mechanism of chronic pain in the anterior cingulate cortex using genetically engineered
Susan S Kim1, Giannina Descalzi, Min Zhuo
1Department of Physiology, Faculty of Medicine, University of Toronto, Centre for the Study of Pain, 1 King's College Circle, Toronto, ON, Canada.
Abstract:
Recent advances into the understanding of molecular mechanism of chronic pain have been largely developed through the use of genetic manipulations. This is in part due to the scarcity of selective pharmacological tools, which can be readily solved by creating knockout or transgenic mice. By identifying new genes that are of import, our efforts can then be aimed at studying relevant signaling pathways, and combination of pharmacological manipulations with genetic models can be used to further examine the specific mechanisms involved in chronic pain. In this review, we will examine the genetic models that are currently in use to study chronic pain in the anterior cingulate cortex: knockout mice; transgenic mice; and the strength of combining pharmacology with these genetic models.
