Candida krusei infection presenting as a right ventricular mass in a two month old Infant

Suresh V Patted1, Prabhu C Halkati, Suresh T Yavagal

  • 1Department of Cardiology, KLE University J N Medical College, Belgaum, Karnataka, India.

Insights

Fungal infections in premature infants are increasing. A rare case of Candida krusei caused a right ventricular mass, highlighting the need for strict hygiene and early echocardiography in neonatal intensive care units.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • Rising incidence of fungal infections in neonates, particularly preterm infants, due to increased survival rates and immunocompromised status.
  • Neonatal intensive care units (NICUs) present risks for healthcare-associated (nosocomial) infections due to invasive procedures and monitoring.
  • Candida krusei is an opportunistic pathogen that can cause severe infections in vulnerable infant populations.

Observation:

  • A rare case of a right ventricular mass was identified in a neonate.
  • The mass was confirmed to be secondary to Candida krusei infection.
  • Surgical excision of the fungal mass was performed.

Findings:

  • Candida krusei can manifest as a cardiac mass in neonates, a rare but serious complication.
  • The case underscores the susceptibility of preterm, immunocompromised infants in NICUs to invasive fungal infections.
  • Prompt diagnosis through echocardiography is crucial for effective management.

Implications:

  • Reinforces the critical importance of stringent aseptic techniques and infection control in NICUs.
  • Highlights the necessity of early echocardiographic evaluation for neonates with unexplained symptoms to detect cardiac involvement.
  • Emphasizes the need for heightened awareness and prompt treatment of invasive fungal infections in high-risk infant populations.

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...