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[CNS-active substances: synthesis of epoxybenzoxocines]
1Institut für Pharmazie und Lebensmittelchemie, Universität München.
Archiv Der Pharmazie
|November 1, 1990
Abstract:
The 2-(2-Bromophenyl)-acetaldehyde acetals 8 are treated with n-BuLi and the aldehydes 7 and 11 to form the hydroxyacetales 9 and 12, respectively. 9 is cyclized under acidic conditions to the epoxybenzoxocine 2; analogously 12 yields the epoxydibenzoxocine 14.