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Updated: Jun 9, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Water diffusion behaviors and transportation properties in transmembrane cyclic hexa-, octa- and decapeptide
Jian Liu1, Jianfen Fan, Min Tang
1College of Chemistry, Chemical Engineering, and Materials Science, Soochow University, Suzhou 215123, China.
Abstract:
Molecular dynamics simulations have been performed on three transmembrane cyclic peptide nanotubes, i.e., 8 × (WL)(n=3,4,5)/POPE (with uniform lengths but various radii) to investigate the radial dependences of the water-chain structures, diffusions, and transportation properties. The diffusions of individual water molecules and collective coordinates of all the channel-water in the three systems are certified as unbiased Brownian motions. From the very good linear relationships between MSDs and time intervals, the diffusion coefficients and transportation permeabilities have been deduced efficiently. Under the hydrostatic pressure differences across the membrane, a net unidirectional water flow rose up, and the osmotic permeabilities were determined. The ratios of the osmotic and diffusion permeabilities (p(f)/p(d)) were examined for all the three channels.
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