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Bullous pemphigoid and malignancy.

L J Ortíz1, M Vázquez, J L Sánchez

  • 1Department of Dermatology, University of Puerto Rico, School of Medicine, San Juan 00936-5067.

Boletin De La Asociacion Medica De Puerto Rico
|October 1, 1990
PubMed
Summary
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Bullous pemphigoid (BP) is not linked to a higher risk of internal cancers in Puerto Rican patients. Extensive cancer screening is not recommended for BP patients unless clinically indicated.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Bullous pemphigoid (BP) has been historically associated with internal malignancies in medical literature.
  • Previous studies suggest a potential link between BP and various cancers.

Purpose of the Study:

  • To investigate the incidence of internal malignancy in Puerto Rican patients diagnosed with bullous pemphigoid.
  • To determine if BP in this specific population warrants extensive cancer screening.

Main Methods:

  • A retrospective study of forty patients with bullous pemphigoid at the Dermatology Clinics of the Puerto Rico Medical Center.
  • Comparison of malignancy rates in BP patients with the general population, matched for age, sex, and study period.

Main Results:

  • Puerto Rican patients with bullous pemphigoid did not exhibit an increased incidence of internal malignancy.

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  • The observed incidence of malignancy was comparable to the general population.

    • Conclusions:

    • Extensive diagnostic studies for internal malignant neoplasms are not indicated as standard care for all bullous pemphigoid patients.
    • Further investigations for malignancy in BP patients should be guided by individual clinical history and physical examination findings.