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Related Experiment Video

Updated: Jun 9, 2026

Real-Time Void Spot Assay

Real-Time Void Spot Assay

Published on: February 10, 2023

Vulnerable elderly patients and overactive bladder syndrome.

Stephen R Kraus¹, Tamara Bavendam, Tiffany Brake

¹Department of Urology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA. KrausS@uthscsa.edu

|September 3, 2010

Summary

Overactive bladder (OAB) affects the elderly, increasing with age. While treatments exist, more research is needed for vulnerable older adults, focusing on tailored interventions and clinical trial inclusion.

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Detrusor Underactivity Model in Rats by Conus Medullaris Transection

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Published on: August 28, 2020

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Last Updated: Jun 9, 2026

Real-Time Void Spot Assay

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Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

Gerontology
Urology
Geriatric Medicine

Background:

Overactive bladder (OAB) prevalence rises with age, impacting the growing elderly population, especially those over 75.
OAB symptoms in the elderly are linked to comorbidities like bowel issues, falls, and increased mortality.
Age-related physiological changes and polypharmacy complicate OAB management in older adults.

Purpose of the Study:

To review the efficacy and tolerability of OAB treatments in the elderly, with a focus on vulnerable populations.
To highlight the need for better representation of vulnerable elderly individuals in clinical trials.
To discuss the role of antimuscarinics and behavioral interventions in managing OAB in older adults.

Main Methods:

Review of clinical trial data and existing literature on OAB treatments in elderly populations.
Analysis of age-related factors influencing OAB management and treatment outcomes.
Examination of recommendations for treating urinary incontinence in frail elderly individuals.

Main Results:

Current OAB treatments are generally effective and well-tolerated in elderly patients, though trials often exclude the most vulnerable.
Antimuscarinics show efficacy in improving OAB symptoms and quality of life, but constipation is a concern in vulnerable groups.
Behavioral interventions may be effective and safe, potentially enhancing antimuscarinic efficacy.

Conclusions:

OAB management in the elderly requires careful consideration of comorbidities and age-related changes.
Vulnerable elderly populations need greater representation in clinical trials, with tailored outcome measures.
A combination of behavioral interventions and cautious use of antimuscarinics is recommended for OAB in frail elderly individuals.