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[Parathyroid hormone-related peptide (PTHrP)]
1INRA Theix, Unité métabolisme minéral et ostéogénèse, St-Genès-Champanelle, France.
Reproduction, Nutrition, Development
|January 1, 1990
Summary
Parathyroid hormone-related protein (PTHrP) regulates calcium in mammals. This protein is crucial for fetal calcium transfer and may influence milk calcium secretion and newborn calcium metabolism.
Area of Science:
- Endocrinology
- Comparative Physiology
- Biochemistry
Context:
- Parathyroid hormone-related protein (PTHrP) shares functional similarities with parathyroid hormone (PTH).
- PTHrP plays a role in calcium homeostasis during pregnancy and lactation.
- Humoral hypercalcemia of malignancy is associated with PTHrP.
Purpose:
- To investigate the physiological roles of PTHrP beyond its association with hypercalcemia.
- To explore PTHrP's function in fetal-maternal calcium transfer.
- To elucidate PTHrP's potential role in milk calcium secretion and neonatal calcium metabolism.
Summary:
- PTHrP acts on bone and kidney similarly to PTH.
- Fetal PTHrP stimulates placental calcium transport, maintaining the dam-to-fetus calcium gradient in ewes.
- PTHrP in mammary glands, colostrum, and milk suggests a role in milk calcium secretion and neonatal calcium regulation.
Impact:
- Provides insights into the diverse physiological functions of PTHrP.
- Highlights PTHrP's importance in calcium metabolism across different life stages and species.
- Contributes to understanding calcium regulation in pregnancy, lactation, and neonatal development.