Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Insufficient Sleep and Sleep Deprivation

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

Cause and Effect

Cause and Effect

While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

Diabetes Mellitus: Introduction

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From language matters to stigma-free communication in diabetes: Evolution, challenges, and next steps.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

Sleep-wake cycle impairment adding on the risk for COVID-19 severity in people with diabetes.

Sleep science (Sao Paulo, Brazil)·2020

Same author

Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications.

Chronobiology international·2020

Same author

COVID-19 associated with diabetes and other noncommunicable diseases led to a global health crisis.

Diabetes research and clinical practice·2020

Same author

Depressive symptoms and chronotypes of elderly nursing home residentes: A case management study.

Dementia & neuropsychologia·2020

Same author

Afternoon School Start Times Are Associated with a Lack of Both Social Jetlag and Sleep Deprivation in Adolescents.

Journal of biological rhythms·2020

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Diabetes and sleep: a complex cause-and-effect relationship.

Mark T U Barone¹, Luiz Menna-Barreto

¹Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil. mbarone@icb.usp.br

Diabetes Research and Clinical Practice

|September 3, 2010

Summary

Diabetes and sleep impairment share a bidirectional relationship, forming a vicious cycle. Poor sleep can worsen diabetes control and risk, while diabetes can lead to sleep disorders, impacting overall health.

More Related Videos

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Jun 9, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Area of Science:

Endocrinology
Sleep Medicine
Metabolic Disorders

Background:

Diabetes mellitus (type 1 and type 2) is frequently associated with sleep disturbances.
The relationship between diabetes and sleep impairment is complex and bidirectional.

Purpose of the Study:

To review current evidence and hypotheses on the association between diabetes and sleep impairment.
To highlight novel findings on the neuro-endocrine-metabolic mechanisms mediating this relationship.
To explore potential therapeutic strategies targeting both conditions.

Main Methods:

Literature review of existing evidence and hypotheses.
Discussion of neuro-endocrine-metabolic mediation pathways.
Analysis of the impact of sleep impairment on diabetes and vice versa.

Main Results:

A vicious cycle exists where sleep disorders can promote type 2 diabetes or worsen metabolic control in both types.
Diabetes, particularly with poor metabolic control, is often linked to subsequent sleep disorders.
Novel findings illuminate the complex interplay of neuro-endocrine-metabolic factors.

Conclusions:

Understanding the mechanisms underlying the diabetes-sleep impairment cycle is crucial.
This understanding can inform the development of novel therapeutic strategies.
Interventions targeting both sleep and diabetes may improve patient outcomes.