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Perioperative stroke after total joint arthroplasty: prevalence, predictors, and outcome
S M Javad Mortazavi1, Hasan Kakli, Orhan Bican
1Rothman Institute of Orthopedics, Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Insights
Perioperative stroke is a rare but serious complication after total joint arthroplasty. Identifying risk factors like heart disease and urgent surgery can help prevent these devastating events.
Area of Science:
- Orthopedic Surgery
- Neurology
- Public Health
Background:
- Perioperative stroke is a known risk in cardiac and carotid surgery.
- This complication is often overlooked following total joint arthroplasty (TJA).
- Understanding TJA-related stroke prevalence and risk factors is crucial.
Purpose of the Study:
- Determine the prevalence and outcomes of perioperative stroke after TJA.
- Identify patient and surgery-related risk factors for stroke.
- Develop strategies to minimize stroke incidence post-TJA.
Main Methods:
- Observational study of 18,745 patients undergoing hip or knee arthroplasty (2000-2007).
- Analysis of institutional stroke rate (0.2%).
- Evaluation of patient and surgical factors using a predictive model.
Main Results:
- The perioperative stroke rate was 0.2% (36/18,745 patients).
- First-year mortality for stroke patients was 25%.
- Significant predictors included noncoronary heart disease, urgent surgery, general anesthesia, and intraoperative arrhythmias.
Conclusions:
- Perioperative stroke is a rare but severe complication of TJA.
- High morbidity and mortality rates are associated with TJA-related stroke.
- Timely prevention, detection, and treatment are vital for improving outcomes.
Background:
The risk of perioperative stroke following cardiac and carotid artery surgery is well documented. There is an apparent lack of recognition and appreciation of this complication after total joint arthroplasty. The present study was designed to determine the prevalence of, and outcome after, perioperative stroke following total joint arthroplasty. In addition, risk factors for the development of this complication were evaluated in an attempt to identify a strategy that could minimize the prevalence of this complication.
Methods:
We performed an observational study of 18,745 consecutive patients undergoing primary or revision total hip or total knee arthroplasty from 2000 to 2007 at our institution. The institutional perioperative stroke rate was 0.2% (thirty-six of 18,745). The thirty-six patients who had a stroke included seventeen men and nineteen women with a mean age of 68.2 years (range, forty-five to eighty-seven years). The average duration of follow-up for all patients and controls in the present study was sixty-two months (range, zero to 124.9 months). In a predictive model, different patient-related and surgery-related factors that could predispose patients to this complication and/or affect outcome were evaluated.
Results:
The first-year mortality among stroke patients was 25% (nine of thirty-six), and four of these nine patients died in the hospital following total joint arthroplasty. Of three patients who received emergency intra-arterial thrombolysis, two had complete neurologic recovery and one died in the hospital. The final regression model showed that a history of noncoronary heart disease, urgent (versus elective) surgery, general (versus regional) anesthesia, and an intraoperative arrhythmia or other alterations in the heart rate during surgery are significant predictors of perioperative stroke.
Conclusions:
Perioperative stroke is a rare but potentially devastating complication of total joint arthroplasty, with a high rate of morbidity and mortality. Vigilant attention to prevent, detect, and treat this complication in a timely manner may alter the course of the disease.
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