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Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Additives and Fillers in Concrete01:29

Additives and Fillers in Concrete

Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

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Related Experiment Video

Updated: Jun 9, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Bone void fillers.

John S Kirkpatrick1, Charles N Cornell, Bang H Hoang

  • 1University of Florida, Jacksonville, FL, USA.

The Journal of the American Academy of Orthopaedic Surgeons
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

This review evaluates synthetic bone void fillers for bone grafting. Evidence suggests their effectiveness alone or as graft extenders, potentially replacing iliac crest bone graft.

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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Evidence-Based Medicine

Background:

  • Bone void fillers are crucial in orthopedic procedures.
  • Synthetic graft materials offer alternatives to traditional bone grafts.
  • Evaluating their clinical efficacy is essential for surgical decision-making.

Purpose of the Study:

  • To summarize evidence on the effectiveness and clinical outcomes of synthetic bone void fillers.
  • To assess synthetic fillers used alone and as graft extenders.
  • To compare synthetic fillers with allografts in spinal applications.

Main Methods:

  • Utilized evidence-based medicine principles for a technology overview.
  • Conducted comprehensive literature searches to address specific research questions.
  • Focused on synthetic graft materials for bone void filling.

Main Results:

  • Effectiveness of synthetic bone void fillers used alone was examined.
  • Assessed the potential of synthetic fillers to replace iliac crest bone graft as extenders.
  • Compared clinical outcomes of synthetic fillers with allografts in spinal surgery.

Conclusions:

  • Synthetic bone void fillers show promise in orthopedic applications.
  • Further research is needed to fully elucidate their role compared to allografts.
  • These materials may offer viable alternatives for bone defect management.