Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of an educational podcast on emotional wellbeing and attitudes towards Charles Bonnet syndrome hallucinations.

Therapeutic advances in ophthalmology·2026
Same author

Location of visual field defects and their impact on vision-related quality of life in glaucoma: A systematic review.

Optometry and vision science : official publication of the American Academy of Optometry·2026
Same author

Longitudinal Visual Field and Quality-of-Life Change in the Treatment for Advanced Glaucoma Study.

Ophthalmology·2026
Same author

Loneliness and Mental Wellbeing in People With Inherited Macular Disease.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

Archetypes of Binocular Visual Field Loss and Their Impact on Vision-Related Quality of Life in Glaucoma Patients.

Investigative ophthalmology & visual science·2026
Same author

Assessing the resilience of portable vision tests to an uncontrolled home environment.

PeerJ·2026
Same journal

Loss of ATRAID in Late-Onset, Non-Syndromic Retinitis Pigmentosa.

Investigative ophthalmology & visual science·2026
Same journal

Whole-Exome Analysis Identifies Candidate Genes Associated With Diabetic Retinopathy.

Investigative ophthalmology & visual science·2026
Same journal

Antiseptic Efficacy and Ocular Surface Toxicity of Povidone-Iodine and Chlorhexidine for Endophthalmitis Isolates.

Investigative ophthalmology & visual science·2026
Same journal

Ocular IL-1α/IFN-γ Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.

Investigative ophthalmology & visual science·2026
Same journal

New Guidelines for Ophthalmic Genetic Studies.

Investigative ophthalmology & visual science·2026
Same journal

Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss
07:12

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss

Published on: April 11, 2025

Task-specific fixation behavior in macular disease.

Michael D Crossland1, David P Crabb, Gary S Rubin

  • 1UCL Institute of Ophthalmology, London, United Kingdom. m.crossland@ucl.ac.uk

Investigative Ophthalmology & Visual Science
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

Individuals with macular disease use different retinal areas for reading words versus fixating a point. This finding is crucial for understanding visual function in central vision loss.

More Related Videos

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss
07:12

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss

Published on: April 11, 2025

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vision Science

Background:

  • Central scotomas, often resulting from macular disease, impair vision by creating blind spots.
  • Individuals with central scotomas typically develop a preferred retinal locus (PRL) to compensate for the damaged fovea.
  • Understanding fixation behavior is critical for visual rehabilitation strategies.

Purpose of the Study:

  • To investigate whether the retinal locus used for fixating a point target is consistent with that used for reading words in individuals with central scotomas.
  • To compare fixation behavior during point fixation and word reading tasks in patients with macular disease.

Main Methods:

  • Recruited nine subjects with macular disease and bilateral central scotomas.
  • Measured retinal fixation areas for point targets and text using a microperimeter.
  • Employed a nonparametric spatial statistical technique to analyze fixation point consistency.

Main Results:

  • Fixation points differed significantly between point fixation and word reading tasks in all subjects with macular disease (P<0.01).
  • Fixation stability was poorer during word reading compared to point fixation (P<0.05).
  • Control subjects without macular disease showed no significant difference in fixation distribution between tasks (P>0.3).

Conclusions:

  • Fixation behavior in individuals with macular disease is task-dependent, varying between fixating a point and reading words.
  • Assessing fixation to a discrete point target may not accurately reflect a patient's overall fixation performance during functional tasks like reading.
  • These findings highlight the need for task-specific assessments of visual function in patients with central vision loss.