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Indeterminate Structure01:18

Indeterminate Structure

Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and some...
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The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
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Procedure for Lung Engineering
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Scaffold engineering: a bridge to where?

Scott J Hollister1

  • 1Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, 2208 Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA. scottho@umich.edu

Biofabrication
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

The tissue engineering field needs a new research model. Focusing on scalable manufacturing for specific clinical uses, rather than just discovery, will speed up product translation and regulatory approval.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Significant federal funding ($4 billion+) has fueled tissue engineering research, increasing publications but yielding few products.
  • A major gap exists between tissue engineering research and clinical translation, hindering product development.
  • Current linear research models prioritize discovery over scalable manufacturing and specific clinical applications.

Purpose of the Study:

  • To identify the reasons for the gap between tissue engineering research and clinical translation.
  • To propose a new research paradigm, inspired by Pasteur's Quadrant, to improve translation.
  • To advocate for increased funding emphasis on scalable manufacturing for specific, regulated clinical applications.

Main Methods:

  • Analysis of the current linear research model in tissue engineering.
  • Proposal of an alternative research paradigm based on Pasteur's Quadrant (simultaneous pursuit of fundamental understanding and end-use).
  • Discussion of the benefits of focusing on manufacturing technologies for scaffold/cell systems.

Main Results:

  • The linear model, heavily focused on discovery, leads to technologies not engineered for clinical use or scalability.
  • Adopting a Pasteur's Quadrant approach, emphasizing manufacturing for specific applications, can accelerate translation.
  • Investment in scalable manufacturing can facilitate regulatory approval and enable advanced basic science research.

Conclusions:

  • A shift from a discovery-centric linear model to an application-focused, manufacturing-centric paradigm is crucial for tissue engineering.
  • Prioritizing scalable manufacturing for specific clinical applications will bridge the 'Valley of Death' and speed regulatory approval.
  • This new approach will enhance the translation of tissue engineering technologies and broaden fundamental scientific understanding, particularly in cell therapy and 3D environments.