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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 9, 2026

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
07:46

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Stemming vision loss with stem cells.

Valentina Marchetti1, Tim U Krohne, David F Friedlander

  • 1Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.

The Journal of Clinical Investigation
|September 3, 2010
PubMed
Summary
This summary is machine-generated.

Stem cell therapies show promise for treating eye diseases, particularly for the ocular surface and challenging back-of-the-eye conditions. These regenerative medicine approaches aim to preserve or restore vision through cell replacement or supportive effects.

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Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
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Last Updated: Jun 9, 2026

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
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Published on: October 6, 2023

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Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

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Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
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Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model

Published on: January 26, 2024

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cell research offers potential treatments for various diseases.
  • The eye is a prime target for cell-based therapies due to accessibility and disease prevalence.
  • Ocular surface diseases have seen successful stem cell treatment, preserving vision.

Purpose of the Study:

  • To explore the potential of stem cell therapies for treating diverse eye conditions.
  • To highlight the challenges and promise of stem cell applications for posterior eye diseases.
  • To discuss the role of stem cells in vision preservation and restoration.

Main Methods:

  • Review of current stem cell research in ophthalmology.
  • Analysis of stem cell applications for ocular surface diseases.
  • Evaluation of emerging stem cell technologies for back-of-the-eye diseases.

Main Results:

  • Stem cell therapies have successfully treated ocular surface diseases, preserving vision.
  • Diseases like macular degeneration and diabetic retinopathy present significant challenges for treatment.
  • Emerging technologies offer potential for autologous grafts to stabilize vision loss.

Conclusions:

  • Stem cell therapy is a promising avenue for treating a range of ocular conditions.
  • Cellular replacement and paracrine effects are key mechanisms for vision stabilization.
  • Further research into stem cell technologies is crucial for advancing eye disease treatment.