Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polarity of the Cytoskeleton01:18

Polarity of the Cytoskeleton

The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Potential Due to a Polarized Object01:29

Potential Due to a Polarized Object

A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
Formation of Intermediate Filaments00:57

Formation of Intermediate Filaments

Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been reported.
Magnetic Fields01:27

Magnetic Fields

A moving charge or a current creates a magnetic field in the surrounding space, in addition to its electric field. The magnetic field exerts a force on any other moving charge or current that is present in the field. Like an electric field, the magnetic field is also a vector field. At any position, the direction of the magnetic field is defined as the direction in which the north pole of a compass needle points.
A magnetic field is defined by the force that a charged particle experiences...
Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
Microtubules and motor proteins exert two types of forces on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanics and thermodynamics of the living cell, dedicated to Erich Sackmann.

Biophysical journal·2026
Same author

Midline Palatal Ectopic Tooth: A Case Report.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·2026
Same author

AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Self-folding graphene scaffolds with integrated electronics for cardiac tissue engineering.

Nanoscale·2026
Same author

Reconstituted nascent adhesion condensates drive actin polymerization on supported lipid bilayers.

Science advances·2026
Same author

Pattern Formation Beyond Turing: Physical Principles of Mass-Conserving Reaction-Diffusion Systems.

Annual review of biophysics·2026

Related Experiment Video

Updated: Jun 9, 2026

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments
07:56

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments

Published on: January 7, 2019

Polar patterns of driven filaments.

Volker Schaller1, Christoph Weber, Christine Semmrich

  • 1Lehrstuhl für Biophysik-E27, Technische Universität München, 85748 Garching, Germany.

Nature
|September 3, 2010
PubMed
Summary

Scientists created a minimal system of actin filaments and molecular motors to study self-organization. This system exhibits collective motion and pattern formation, revealing essential local alignment interactions for active fluid dynamics.

More Related Videos

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
08:02

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Published on: May 5, 2022

Biophysical Characterization of Flagellar Motor Functions
06:08

Biophysical Characterization of Flagellar Motor Functions

Published on: January 18, 2017

Related Experiment Videos

Last Updated: Jun 9, 2026

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments
07:56

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments

Published on: January 7, 2019

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
08:02

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Published on: May 5, 2022

Biophysical Characterization of Flagellar Motor Functions
06:08

Biophysical Characterization of Flagellar Motor Functions

Published on: January 18, 2017

Area of Science:

  • Physics of active matter
  • Soft matter physics
  • Biophysics

Background:

  • Collective motion is a common self-organization phenomenon in nature.
  • Theoretical models exist but lack experimental verification due to system complexity.

Purpose of the Study:

  • To demonstrate and understand collective motion in a controllable experimental system.
  • To identify the fundamental interactions driving pattern formation in active fluids.

Main Methods:

  • Utilized a high-density motility assay with actin filaments and molecular motors.
  • Employed agent-based simulations to analyze assembly and disassembly pathways.
  • Controlled system parameters to study emergent behaviors.

Main Results:

  • Observed self-organization into moving structures (clusters, swirls, bands) above a critical density.
  • Demonstrated long-lived polar nematic structures spanning large length scales.
  • Identified weak, local alignment interactions as crucial for pattern dynamics.

Conclusions:

  • The minimal system provides a platform for studying active fluid dynamics.
  • Weak local alignment is essential for emergent collective motion and pattern formation.
  • Offers insights into universal principles of self-organization in active matter.