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Updated: Jun 9, 2026
Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
Molecular genetics, imaging and treatment of oligodendroglial tumours
Michael D Jenkinson1, Carol Walker, Andrew R Brodbelt
1Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK. michael.jenkinson@liv.ac.uk
Abstract:
The discovery of a genetic signature of chemosensitivity and prognosis in oligodendroglial tumours prompted a new optimism in glioma management. After more than a decade since the initial reports, where do we stand in the current management of oligodendroglial tumours? This review focuses on the latest molecular genetics, imaging characteristics, and recent trials of treatment paradigms for these tumours.
Insights
Oligodendroglial tumors now have improved management due to genetic markers predicting treatment response. This review details the latest molecular, imaging, and treatment advances for these gliomas.
Area of Science:
- Neuro-oncology
- Molecular Genetics
- Cancer Imaging
Background:
- Oligodendroglial tumors represent a significant challenge in neuro-oncology.
- Initial discovery of genetic signatures offered new hope for targeted glioma management.
- Over a decade of research necessitates an updated review of current practices.
Purpose of the Study:
- To review the current status of oligodendroglial tumor management.
- To highlight recent advancements in molecular genetics relevant to these tumors.
- To discuss updated imaging characteristics and treatment strategies.
Main Methods:
- Comprehensive literature review of molecular genetics in oligodendroglial tumors.
- Analysis of recent clinical trials and treatment paradigms.
- Evaluation of advanced imaging techniques for tumor characterization.
Main Results:
- Genetic signatures significantly impact chemosensitivity and prognosis.
- Molecular subtyping refines diagnostic and therapeutic approaches.
- Emerging imaging modalities improve diagnostic accuracy.
Conclusions:
- Genetic profiling is crucial for personalized oligodendroglial tumor treatment.
- Integration of molecular data and advanced imaging optimizes patient outcomes.
- Continued research in treatment paradigms is essential for improving glioma management.
