Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liquid chromatographic methods validation for pharmaceutical products.

T D Wilson1

  • 1Sterling Research Group, Rensselaer, NY 12144.

Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of incremental maxillomandibular advancement surgery on airway morphology: a cadaveric study.

International journal of oral and maxillofacial surgery·2024
Same author

Effects of postural changes and removal of vestibular inputs on blood flow to and from the hindlimb of conscious felines.

American journal of physiology. Regulatory, integrative and comparative physiology·2009
Same author

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow.

American journal of physiology. Regulatory, integrative and comparative physiology·2006
Same author

Vestibular inputs elicit patterned changes in limb blood flow in conscious cats.

The Journal of physiology·2006
Same author

Effects of postural changes and removal of vestibular inputs on blood flow to the head of conscious felines.

Journal of applied physiology (Bethesda, Md. : 1985)·2006
Same author

Circulating norepinephrine and cerebrovascular control in conscious humans.

Clinical physiology and functional imaging·2003
Same journal

Analyzing the impact of ionizable lipid identity, purity, and stability on lipid nanoparticle performance.

Journal of pharmaceutical and biomedical analysis·2026
Same journal

Application of two-dimensional liquid chromatography as a complementary technique to circular dichroism spectroscopy and high-resolution mass spectrometry for the characterization of GalNAc-siRNA conjugates.

Journal of pharmaceutical and biomedical analysis·2026
Same journal

The transfer of per- and polyfluoroalkyl substances (PFAS) from mother to child: Comparison between maternal and cord blood in an Italian cohort.

Journal of pharmaceutical and biomedical analysis·2026
Same journal

UHPLC/Q-TOF-MS-based blood-component profiling and multi-omics analysis reveal potential protective mechanisms of Shenzhuo Formula against diabetic kidney disease.

Journal of pharmaceutical and biomedical analysis·2026
Same journal

Multi-center study of the recombinant cascade reagent (kinetic chromogenic assay) as an alternative method for bacterial endotoxin testing: Method validation, product suitability, and consistency evaluation with limulus amebocyte lysate.

Journal of pharmaceutical and biomedical analysis·2026
Same journal

Simultaneous enantioselective separation of 2-, 3- and 4-chloromethcathinones using supercritical fluid chromatography-tandem mass spectrometry and its application to human oral fluid samples.

Journal of pharmaceutical and biomedical analysis·2026
See all related articles

This review examines validation methods for liquid chromatography (LC) in pharmaceutical analysis, focusing on compatibility testing. It details key validation parameters including linearity, accuracy, precision, and system suitability for robust drug analysis.

Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Analysis
  • Chromatography

Background:

  • Ensuring the reliability of analytical methods is crucial in pharmaceutical quality control.
  • Liquid chromatography (LC) is a cornerstone technique for drug analysis.
  • Method validation provides the framework for assessing the suitability of analytical procedures.

Purpose of the Study:

  • To review the current state of validation for LC methods in pharmaceutical analysis.
  • To specifically highlight the importance and methods of compatibility testing.
  • To consolidate essential validation parameters for robust pharmaceutical analysis.

Main Methods:

  • Review of existing literature and guidelines on LC method validation.
  • Focus on compatibility testing methodologies within validation frameworks.

Related Experiment Videos

  • Analysis of validation data encompassing linearity, accuracy, precision, and system suitability.

    • Main Results:

    • Comprehensive overview of critical validation parameters for LC methods.
    • Detailed examination of factors influencing method compatibility and reliability.
    • Inclusion of specificity, alternate methods, injection order, and measurement types (peak height/area, internal/external standards).

    Conclusions:

    • Robust validation of LC methods is essential for accurate pharmaceutical analysis.
    • Compatibility testing is a critical component of a thorough validation strategy.
    • Adherence to standardized validation parameters ensures data integrity and regulatory compliance.