[Psoriasis as an independent risk factor for development of coronary artery disease]

D Papo1, R Hein, J Ring

  • 1Klinik und Poliklinik für Dermatologie und Allergologie der Technischen Universität München. davidpapo@58beats.com

Insights

Psoriasis patients have higher rates of cardiovascular disease due to shared risk factors and psoriasis potentially being an independent risk factor. Research explores common immunopathogenetic mechanisms linking these conditions.

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Context:

  • Psoriasis is a chronic inflammatory skin disease with a frequent relapsing course.
  • Psoriatic arthritis is a well-known comorbidity.
  • Patients with psoriasis often exhibit classic cardiovascular risk factors like obesity, diabetes mellitus, hyperlipoproteinemia, hypertension, and nicotine abuse, frequently presenting as Metabolic Syndrome.

Purpose:

  • To review the current research on the association between psoriasis and cardiovascular disease.
  • To discuss potential shared immunopathogenetic mechanisms linking psoriasis and cardiovascular risk.

Summary:

  • Numerous studies demonstrate that patients with psoriasis suffer more frequently from coronary heart disease compared to those without psoriasis.
  • Emerging evidence suggests psoriasis may act as an independent cardiovascular risk factor, even when accounting for traditional risk factors.
  • The review synthesizes current knowledge on this association and explores underlying common inflammatory pathways.

Impact:

  • Highlights psoriasis as a significant factor in cardiovascular risk assessment.
  • Emphasizes the need for integrated management of psoriasis and cardiovascular health.
  • Provides insights into potential therapeutic targets for both conditions by understanding shared mechanisms.

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