Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration
Mohammad Reza Khoshayand1, Hamid Abdollahi, Ali Moeini
1Department of Drug and Food Control, Tehran University of Medical Sciences, Iran. khoshayand@tums.ac.ir
Abstract:
Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural network (PC-ANN) analysis were investigated for their application to the simultaneous determination of chlordiazepoxide and clidinium levels in pharmaceuticals. A set of synthetic mixtures of drugs in ethanol and 0.1 M HCL was made, and the prediction abilities of the aforementioned methods were examined using RSE% (relative standard error of the prediction). The PLS and PC-ANN methods were found to be comparable, and GA-PLS produced slightly better results. The predictive models that we built were successfully applied to simultaneously determine the levels of chlordiazepoxide and clidinium in coated tablets.
More Related Videos
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
07:29HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
Published on: November 11, 2022
Related Concept Videos
Calibration Curves: Linear Least Squares
For data that follow a straight line, the standard method for fitting is the linear...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Instrument Calibration
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...
Precipitation Titration: Endpoint Detection Methods
In the Volhard method, a standard excess of AgNO3 is first added to the...
Flame Photometry: Lab
