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Updated: Jun 9, 2026

Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
The atria: from morphology to function
Domenico Corradi1, Roberta Maestri, Emilio Macchi
1Department of Pathology and Laboratory Medicine, Section of Pathology, University of Parma, Parma, Italy. domenico.corradi@unipr.it
Insights
This review details atrial anatomy at macroscopic, histological, and ultrastructural levels. It explores normal atrial structure and its changes in atrial fibrillation and heart failure.
Area of Science:
- Cardiovascular Anatomy
- Cardiac Histology
- Electrophysiology
Background:
- Atrial and ventricular disorders like atrial fibrillation and heart failure involve structural changes and atrial myocardial remodeling.
- Advances in mapping and ablative procedures for supraventricular arrhythmias highlight the need for detailed atrial anatomy knowledge.
Purpose of the Study:
- To provide a comprehensive overview of left and right atrial structure.
- To correlate atrial structure (macroscopic, histological, ultrastructural) with cardiac function.
- To examine functional anatomy in atrial fibrillation and heart failure.
Main Methods:
- Review of existing literature on atrial gross anatomy.
- Analysis of histological and ultrastructural studies of atrial tissue.
- Correlation of structural findings with functional implications in disease states.
Main Results:
- Detailed description of normal atrial anatomy at multiple levels.
- Identification of structural remodeling patterns in atrial fibrillation.
- Characterization of atrial structural changes associated with heart failure.
Conclusions:
- Understanding atrial structure is crucial for diagnosing and treating arrhythmias and heart failure.
- Atrial remodeling significantly impacts cardiac function and disease progression.
- Comprehensive knowledge of atrial anatomy aids in developing effective therapeutic strategies.
Abstract:
The fact that some atrial and ventricular disorders (e.g., atrial fibrillation and heart failure) have a structural basis and cause atrial myocardial remodeling has led to increasing attention being paid to the atrial chambers. Furthermore, the rapid development of mapping and ablative procedures as a means of diagnosing and treating supraventricular arrhythmias has generated considerable interest in atrial gross anatomy, histology and ultrastructure. The aim of this article is to provide a comprehensive overview of the structure of the left and right atria (at macroscopic, histological and ultrastructural level) in relation to their function. In addition to analyzing normal atria, we also discuss functional anatomy in the case of atrial fibrillation and heart failure.
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