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Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a virus that...
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Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

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Mitochondria and viruses.

Akane Ohta1, Yukihiro Nishiyama

  • 1Department of Virology, Graduate School of Medicine, Nagoya University, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.

Mitochondrion
|September 4, 2010
PubMed
Summary
This summary is machine-generated.

Mitochondria are crucial for host defense against viruses. Viral proteins interacting with mitochondria regulate cellular responses during infection, highlighting their central role in antiviral immunity.

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Area of Science:

  • Cellular Biology
  • Virology
  • Immunology

Background:

  • Mitochondria are key regulators of cellular metabolism.
  • Mitochondrial functions are influenced by viral infections.
  • Mitochondria are increasingly recognized for their role in host defense.

Purpose of the Study:

  • To review the functions of mitochondria in antiviral defense.
  • To summarize the roles of viral and mitochondrial proteins in host-virus interactions.
  • To highlight mitochondrial responses to viral infections.

Main Methods:

  • Literature review of recent studies.
  • Analysis of viral protein localization and interactions within mitochondria.
  • Examination of cellular responses mediated by mitochondria.

Main Results:

  • Mitochondria are central to primary host defense against viruses.
  • Novel viral and mitochondrial proteins modulate these defense mechanisms.
  • Viral proteins can localize to mitochondria, influencing cellular responses.

Conclusions:

  • Mitochondria play a critical role in antiviral immunity.
  • Mitochondrial-viral protein interactions are key regulatory points.
  • Understanding these interactions is vital for antiviral strategies.