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Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether
Shelly Sharma1, S K Chattopadhyay, Priyanka Trivedi
1Process Chemistry and Chemical Engineering Department, Central Institute of Medicinal and Aromatic Plants, (Council of Scientific and Industrial Research), P.O. CIMAP, Lucknow-226015, Uttar Pradesh, India.
Abstract:
Six novel cleomiscosin A (a coumarino-lignoid), derivatives have been synthesized for the first time by using electrophilic substitution reaction to give nuclear nitrated and halogenated derivatives of cleomiscosin A in good yields. Structures of these compounds were established on the basis of IR, (1)H NMR, (13)C NMR and Mass spectral data. Some of the synthesized derivatives were tested for in-vitro target based anti-inflammatory study using primary macrophages cell culture bioassay system. The results showed that the compounds 1a, 3a and 4a (1 and 10 μg/mL) exhibited potent anti-inflammatory activity.
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