Related Experiment Video

Updated: Jun 9, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

Annie Yang1, Nicholas S Wilson, Avi Ashkenazi

  • 1Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Current Opinion in Cell Biology
|September 4, 2010
PubMed

Insights

Proapoptotic receptor agonists (PARAs) targeting death receptors 4 and 5 show promise for cancer treatment. Strategies are needed to identify responsive tumors and overcome resistance to maximize anti-tumor effects.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Proapoptotic receptor agonists (PARAs) targeting death receptors (DRs) 4 and 5 offer selective cancer cell killing.
  • Clinical data suggest DR4/5 PARAs are well-tolerated and warrant further investigation.

Purpose of the Study:

  • To review molecular and biological factors influencing cancer cell responsiveness to PARAs.
  • To discuss predictive biomarkers and combination strategies for enhancing PARA efficacy.

Main Methods:

  • Literature review of studies on PARAs, death receptors 4 and 5, and apoptosis resistance.
  • Analysis of molecular determinants of tumor cell sensitivity and resistance.

Main Results:

  • Some cancer cell lines and models exhibit resistance to PARAs.
  • Identifying responsive tumor types and overcoming resistance are crucial for therapeutic success.

Conclusions:

  • Understanding determinants of PARA responsiveness is key.
  • Predictive biomarkers and combination therapies can maximize anti-tumor activity of PARAs.

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