Comparison of outcome in Jehovah's Witness patients in cardiac surgery: an Australian experience
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Published on: February 11, 2022
B Bhaskar1, R K Jack, D Mullany
1The Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland 4032, Australia. drbalubhaskar@yahoo.com
Insights
Cardiac surgery outcomes for Jehovah's Witnesses (JW) are similar to other patients, even without blood transfusions. This study highlights safe cardiac surgery practices for JWs, emphasizing reduced bleeding and comparable mortality rates.
Area of Science:
- Cardiology
- Transfusion Medicine
- Surgical Outcomes
Background:
- Cardiac surgery frequently requires blood transfusions, accounting for a significant portion of all transfusions.
- Advances in medical technology and perioperative care enable Jehovah's Witnesses (JW) to safely undergo complex cardiac procedures without blood products.
Purpose of the Study:
- To systematically compare operative mortality and early clinical outcomes in JW patients undergoing cardiac surgery versus non-JW patients.
- To evaluate the safety and efficacy of cardiac surgical procedures for JWs who refuse blood transfusions.
Main Methods:
- A retrospective analysis of 5353 cardiac surgery patients (2002-2005), including 49 Jehovah's Witnesses (JW).
- Propensity score matching was used to compare outcomes between JW and non-JW groups.
- Outcomes assessed included operative mortality, postoperative variables, and intensive care unit length of stay.
Main Results:
- JW patients had higher baseline and postoperative hemoglobin and hematocrit levels.
- Jehovah's Witnesses experienced significantly less bleeding compared to the control group (P<0.001).
- No significant differences were observed in operative mortality or length of stay between JW and non-JW patients.
Conclusions:
- Cardiac surgery outcomes for Jehovah's Witnesses are comparable to those of patients receiving transfusions.
- The findings support the safety of cardiac surgery for JWs and encourage efforts to minimize allogeneic blood product usage.
Introduction:
Despite the advances in modern medicine, cardiac surgery remains associated with significant amounts of blood transfusion and is responsible for nearly 20% of all transfusions in Australasia. Progressive advances in perfusion technology and perioperative supportive management have made it possible for members of the Jehovah's Witnesses (JW) religious group to undergo open cardiac operations with remarkable safety. This study systematically compares the operative mortality and early clinical outcome after cardiac surgery in JWs.
Methods And Materials:
Data was obtained from the cardiac surgery and intensive care unit databases from January 2002 to December 2005. A total of 5353 patients who underwent cardiac surgical procedures including coronary artery bypass grafting with cardiopulmonary bypass (n=4041) and valvular heart surgery (n=2287) were assessed in this study. Of the 5353 patients 49 patients refused blood and blood products because of their religious beliefs. Models were constructed to determine the association between JWs and non-JWs and three outcomes: (1) operative mortality, (2) postoperative variables and (3) length of stay in intensive care unit. Propensity scores were computed from these models and used to match JWs with non-JWs.
Results:
There were minimal differences in the baseline patient demographic characteristics between the two groups. Haemoglobin and haematocrit levels were higher in JWs both before (13.7g/dL vs 12.8g/dL; P=0.01, and 40.0% vs 39.2%; P=0.08) and after (10.8g/dL vs 9.9g/dL; P=.003, and 34.0% vs 30.9%; P=.001) surgery. Jehovah's Witnesses experienced significantly less bleeding, almost half compared to the control group, with P<0.001. No differences were found in the adjusted and unadjusted operative mortality or intensive care unit and postoperative length of stay between the two groups.
Conclusion:
This study concurs with the international published data that outcomes for JW patients who undergo cardiac surgery are similar to those who receive transfusion. Every appropriate opportunity to reduce the use of allogeneic blood products.
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