Related Experiment Video
Updated: Jun 9, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
[Preparation of As2O3 nanoparticles and its drug release characteristics in vitro]
Li-shu Xu1, Jian-hu Liu, Ping Lin
1Department of Gastroenterology, East District of Guangdong General Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Objective:
To prepare arsenic trioxide (As2O3)-loaded biodegradable polylactic-co-glycolic acid (PLGA) nanoparticles (NPS) and evaluate the glomeration ability, appearance, structure, surface and release characteristics of the NPs.
Methods:
With PLGA as the carrier material, As2O3 NPs (As2O3-NPS) were prepared with the method of matrix and ultrasound emulsification. According to the criteria of the diameter of the NPs, drug loading (DL) and embedding ratio (ER), the process of NP preparation was optimized by scanning electron microscopy (SEM), ultraviolet spectroscopy (UV), and XPS.
Results:
The As2O3-NPS prepared were uniformly spherical with an average diameter of 210-/+23 nm, DL of 29.6% and ER of 82.1%. The drug release assay in vitro showed a sustained drug-release capacity of the preparation.
Conclusion:
As2O3-NPS may serve as a carrier of As2O3 to change the pharmacokinetics of As2O3 in vivo, allow slow drug release, and prolong the drug circulation time after intravenous injection, thereby producing better antitumor effects.
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Bioavailability Enhancement: Drug Solubility Enhancement
Modified-Release Drug Delivery Systems: Bioavailability
In Vitro Drug Release Testing: Overview, Development and Validation
