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Related Experiment Video

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Physical activity and right ventricular structure and function. The MESA-Right Ventricle Study.

Carrie P Aaron1, Harikrishna Tandri, R Graham Barr

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

American Journal of Respiratory and Critical Care Medicine
|September 4, 2010
PubMed
Summary
This summary is machine-generated.

Higher physical activity in older adults is linked to increased right ventricular (RV) mass and volumes. This exercise-associated RV remodeling may have clinical implications.

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Area of Science:

  • Cardiology
  • Exercise Physiology
  • Gerontology

Background:

  • Elite athletes exhibit increased left ventricular (LV) and right ventricular (RV) mass and volumes due to intense exercise.
  • The impact of physical activity on the RV in older, community-based populations remains largely unknown.

Purpose of the Study:

  • To investigate the association between physical activity levels and RV mass and volumes in adults.
  • To determine if physical activity influences RV size independent of LV size.

Main Methods:

  • Cardiac magnetic resonance imaging (MRI) was used to assess RV mass and volumes in community-based participants from the Multi-Ethnic Study of Atherosclerosis (MESA).
  • Physical activity was quantified using metabolic equivalent-minutes per day, derived from self-reported frequency, duration, and intensity.
  • Statistical analyses adjusted for demographics, cardiovascular risk factors, and LV mass.

Main Results:

  • Higher levels of moderate and vigorous physical activity were linearly associated with increased RV mass (P=0.02) after adjustments.
  • Intentional exercise showed a nonlinear association with RV mass, independent of LV mass (P=0.03).
  • Similar associations were observed between higher physical activity levels and larger RV volumes.

Conclusions:

  • Increased physical activity in adults is associated with greater RV mass and volumes, independent of LV mass.
  • Exercise-induced changes in the RV (remodeling) may have significant clinical implications for older adults.