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Updated: Jun 9, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Cellular microparticles as a marker for cerebral vasospasm in spontaneous subarachnoid hemorrhage

Peter Lackner1, Anelia Dietmann, Ronny Beer

  • 1Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. peter.lackner@i-med.ac.at

Stroke
|September 4, 2010
PubMed
Abstract

Insights

Cellular microparticles (MPs) are elevated in spontaneous subarachnoid hemorrhage (SAH) patients. Endothelial MPs may serve as novel biomarkers for cerebral vasospasm (CVS), while platelet MPs indicate neurological damage.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Vascular Biology

Background:

  • Spontaneous subarachnoid hemorrhage (SAH) carries a significant risk of poor outcomes, often due to symptomatic cerebral vasospasm (CVS).
  • Cellular microparticles (MPs) are implicated in vascular disease pathogenesis.
  • The role of MPs in SAH and CVS requires further elucidation.

Purpose of the Study:

  • To investigate the role of cellular microparticles (MPs) in the pathogenesis of cerebral vasospasm (CVS) following spontaneous subarachnoid hemorrhage (SAH).
  • To determine if MPs can serve as predictive biomarkers for CVS and neurological outcomes in SAH patients.

Main Methods:

  • Quantified endothelial, leukocyte, platelet, and erythrocyte MPs in 20 SAH patients over 15 days post-ictus.
  • Assessed cerebral vasospasm (CVS) using transcranial Doppler sonography.
  • Compared MP levels in SAH patients with 20 healthy controls and correlated MP levels with clinical outcomes.

Main Results:

  • SAH patients exhibited elevated levels of endothelial, leukocyte, and erythrocyte MPs compared to controls.
  • Specific endothelial MPs (CD105+, CD62e+) were significantly higher in patients with Doppler-diagnosed CVS, particularly on days of onset.
  • Elevated platelet MPs (CD41+) were associated with cerebral infarction and poorer neurological outcomes (modified Rankin Scale score ≥1).

Conclusions:

  • Endothelial MPs are elevated in SAH patients and correlate with the occurrence of CVS, suggesting potential as novel CVS biomarkers.
  • Platelet MPs may contribute to cerebral infarction pathogenesis in SAH patients, linking them to neurological morbidity.
  • These findings highlight the potential of MPs as diagnostic and prognostic tools in managing SAH complications.

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