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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 9, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

A pilot experimental lateral ridge augmentation study using bone morphogenetic protein 2 in dogs.

Motofumi Yamashita¹, Myron Nevins, Archie A Jones

¹Funakoshi Research Institute of Clinical Periodontology, Fukuoka, Japan.

The International Journal of Periodontics & Restorative Dentistry

|September 4, 2010

Summary

Bone regeneration in the jaw is crucial for dental implants. This study found that recombinant human bone morphogenetic protein 2 (rhBMP-2) with absorbable collagen sponge (ACS) showed promising bone density, similar to autografts.

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

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Last Updated: Jun 9, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Area of Science:

Oral and Maxillofacial Surgery
Biomaterials Science
Regenerative Medicine

Background:

Posterior mandibular bone defects hinder dental implant success.
Existing bone regeneration techniques show variable outcomes.
Combination therapies may improve predictability.

Purpose of the Study:

To evaluate four bone augmentation techniques in canine mandibular defects.
To compare autografts, rhBMP-2/ACS, collagen-ceramic matrix, and rhBMP-2/ACS/collagen-ceramic combinations.

Main Methods:

A chronic mandibular defect model was created in dogs.
Defects were treated with four different regenerative materials.
Implants were placed in regenerated bone, followed by histologic evaluation.

Main Results:

All treatments promoted new bone growth.
Autograft and rhBMP-2/ACS yielded dense bone.
Collagen-ceramic matrices showed residual material and porosity.

Conclusions:

Multiple bone augmentation methods can restore mandibular bone width.
rhBMP-2/ACS demonstrated bone density comparable to autografts.
Further research is needed to optimize regenerative materials.